BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

Although vaccination with BCG prevents disseminated forms of childhood tuberculosis (TB), it does not protect against pulmonary infection or Mycobacterium tuberculosis (Mtb) transmission. In this study, we generated a complete deletion mutant of the Mtb Esx-5 type VII secretion system (Mtb Δesx-5)....

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Vydáno v:Vaccine
Hlavní autoři: Tiwari, Sangeeta, Dutt, Taru S., Chen, Bing, Chen, Mei, Kim, John, Dai, Annie Zhi, Lukose, Regy, Shanley, Crystal, Fox, Amy, Karger, Burton R., Porcelli, Steven A., Chan, John, Podell, Brendan K., Obregon-Henao, Andres, Orme, Ian M., Jacobs, William R., Henao-Tamayo, Marcela
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755135/
https://ncbi.nlm.nih.gov/pubmed/32978002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.08.004
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