BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

Although vaccination with BCG prevents disseminated forms of childhood tuberculosis (TB), it does not protect against pulmonary infection or Mycobacterium tuberculosis (Mtb) transmission. In this study, we generated a complete deletion mutant of the Mtb Esx-5 type VII secretion system (Mtb Δesx-5)....

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Tiwari, Sangeeta, Dutt, Taru S., Chen, Bing, Chen, Mei, Kim, John, Dai, Annie Zhi, Lukose, Regy, Shanley, Crystal, Fox, Amy, Karger, Burton R., Porcelli, Steven A., Chan, John, Podell, Brendan K., Obregon-Henao, Andres, Orme, Ian M., Jacobs, William R., Henao-Tamayo, Marcela
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755135/
https://ncbi.nlm.nih.gov/pubmed/32978002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.08.004
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