BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

Although vaccination with BCG prevents disseminated forms of childhood tuberculosis (TB), it does not protect against pulmonary infection or Mycobacterium tuberculosis (Mtb) transmission. In this study, we generated a complete deletion mutant of the Mtb Esx-5 type VII secretion system (Mtb Δesx-5)....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Vaccine
Prif Awduron: Tiwari, Sangeeta, Dutt, Taru S., Chen, Bing, Chen, Mei, Kim, John, Dai, Annie Zhi, Lukose, Regy, Shanley, Crystal, Fox, Amy, Karger, Burton R., Porcelli, Steven A., Chan, John, Podell, Brendan K., Obregon-Henao, Andres, Orme, Ian M., Jacobs, William R., Henao-Tamayo, Marcela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755135/
https://ncbi.nlm.nih.gov/pubmed/32978002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2020.08.004
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