Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals

Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Dong, Yong, Bai, Ju, Zhang, Yimeng, Zhou, Ya, Pan, Xu, Li, Xiaohong, Zhou, Qiongxiu, Chen, Yijin, Lai, Mowen, Mao, Bin, Bian, Guohui, Feng, Jia, Xie, Fangxin, Chen, Bo, Nakahata, Tatsutoshi, Zhang, Yonggang, Ma, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Cell Development, Differentiation, & Trafficking
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754144/
https://ncbi.nlm.nih.gov/pubmed/32640500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.1A0520-179R
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