Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor

Overexpression of ABCG2 remains a major impediment to successful cancer treatment, because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes clinical multidrug resistance (MDR). Therefore, it is important to uncover effective modulators to circumvent ABCG2-mediated MDR in cance...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Ji, Ning, Cui, Qingbin, Fu, Han, Lin, Lizhu, Yang, Dong-Hua, Fan, Ying-Fang, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753047/
https://ncbi.nlm.nih.gov/pubmed/33364237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.601400
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