Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor

Overexpression of ABCG2 remains a major impediment to successful cancer treatment, because ABCG2 functions as an efflux pump of chemotherapeutic agents and causes clinical multidrug resistance (MDR). Therefore, it is important to uncover effective modulators to circumvent ABCG2-mediated MDR in cance...

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Dades bibliogràfiques
Publicat a:Front Cell Dev Biol
Autors principals: Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Ji, Ning, Cui, Qingbin, Fu, Han, Lin, Lizhu, Yang, Dong-Hua, Fan, Ying-Fang, Chen, Zhe-Sheng
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753047/
https://ncbi.nlm.nih.gov/pubmed/33364237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.601400
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