Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects

The pathogenicity of group A Streptococcus (GAS) is mediated by direct bacterial invasivity and toxin-associated damage. Among the extracellular products, the exotoxin streptolysin O (SLO) is produced by almost all GAS strains. SLO is a pore forming toxin (PFT) hemolitically active and extremely tox...

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Udgivet i:Front Immunol
Main Authors: Vita, Gian Marco, De Simone, Giovanna, Leboffe, Loris, Montagnani, Francesca, Mariotti, Davide, Di Bella, Stefano, Luzzati, Roberto, Gori, Andrea, Ascenzi, Paolo, di Masi, Alessandra
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7752801/
https://ncbi.nlm.nih.gov/pubmed/33363530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.507092
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