Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5

Renal tubule-interstitial fibrosis is related to chronic kidney disease progression and a typical feature of the aging kidney. Epigenetic modifications of fibrosis-prone genes regulate the development of renal fibrosis. As a kind of “epigenetic diet”, soy isoflavone genistein was reported to have re...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ning, Yichun, Chen, Jing, Shi, Yiqin, Song, Nana, Yu, Xiaofang, Fang, Yi, Ding, Xiaoqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751752/
https://ncbi.nlm.nih.gov/pubmed/33364952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.579265
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