Necrostatin-1 Attenuates Cisplatin-Induced Nephrotoxicity Through Suppression of Apoptosis and Oxidative Stress and Retains Klotho Expression

Aim: Cisplatin is an effective chemotherapeutic drug, but the application in clinical is greatly limited by its nephrotoxicity. Necrostatin-1 (Nec-1), an inhibitor of RIP1 kinase, has been reported to inhibit RIP-mediated necroptosis. The aim of this study is to detect the protective effects of Nec-...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ning, Yichun, Shi, Yiqin, Chen, Jing, Song, Nana, Cai, Jieru, Fang, Yi, Yu, Xiaofang, Ji, Jun, Ding, Xiaoqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917042/
https://ncbi.nlm.nih.gov/pubmed/29725301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00384
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