Wird geladen...
CDKN1B/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cells
The tumor suppressor CDKN1B/p27(Kip1) binds to and inhibits cyclin-CDK complexes in the nucleus, inducing cell cycle arrest. However, when in the cytoplasm, CDKN1B may promote tumorigenesis. Notably, cytoplasmic CDKN1B was reported to promote macroautophagy/autophagy in response to nutrient shortage...
Gespeichert in:
| Veröffentlicht in: | Autophagy |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2020
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7751672/ https://ncbi.nlm.nih.gov/pubmed/33016184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1831217 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|