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CDKN1B/p27 regulates autophagy via the control of Ragulator and MTOR activity in amino acid-deprived cells
The tumor suppressor CDKN1B/p27(Kip1) binds to and inhibits cyclin-CDK complexes in the nucleus, inducing cell cycle arrest. However, when in the cytoplasm, CDKN1B may promote tumorigenesis. Notably, cytoplasmic CDKN1B was reported to promote macroautophagy/autophagy in response to nutrient shortage...
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| Udgivet i: | Autophagy |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7751672/ https://ncbi.nlm.nih.gov/pubmed/33016184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1831217 |
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