Predicting mechanism of action of cellular perturbations with pathway activity signatures

MOTIVATION: Misregulation of signaling pathway activity is etiologic for many human diseases, and modulating activity of signaling pathways is often the preferred therapeutic strategy. Understanding the mechanism of action (MOA) of bioactive chemicals in terms of targeted signaling pathways is the e...

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Bibliografische gegevens
Gepubliceerd in:Bioinformatics
Hoofdauteurs: Ren, Yan, Sivaganesan, Siva, Clark, Nicholas A, Zhang, Lixia, Biesiada, Jacek, Niu, Wen, Plas, David R, Medvedovic, Mario
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
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Original Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751003/
https://ncbi.nlm.nih.gov/pubmed/32653926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa590
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