Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem–loop RNAs and their implications for functional cellular assays

Identifying small molecules that selectively bind an RNA target while discriminating against all other cellular RNAs is an important challenge in RNA-targeted drug discovery. Much effort has been directed toward identifying drug-like small molecules that minimize electrostatic and stacking interacti...

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Publicado no:RNA
Main Authors: Kelly, Megan L., Chu, Chia-Chieh, Shi, Honglue, Ganser, Laura R., Bogerd, Hal P., Huynh, Kelly, Hou, Yuze, Cullen, Bryan R., Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749633/
https://ncbi.nlm.nih.gov/pubmed/33028652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.076257.120
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