The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects

Human SH2B3 is involved in growth factor and inflammation signaling. A SH2B3 missense variant (rs3184504) is associated with cardiovascular diseases plus breast, colorectal, and lung cancers, with highly correlated variants across the ATXN2/SH2B3/BRAP locus linked to parental age at death, suggestin...

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Bibliografiska uppgifter
I publikationen:J Gerontol A Biol Sci Med Sci
Huvudupphovsmän: Kuo, Chia-Ling, Joaquim, Micaella, Kuchel, George A, Ferrucci, Luigi, Harries, Lorna W, Pilling, Luke C, Melzer, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749196/
https://ncbi.nlm.nih.gov/pubmed/31428775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glz191
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