Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in No...

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Vydáno v:Nat Commun
Hlavní autoři: Nielsen, Jonas B., Rom, Oren, Surakka, Ida, Graham, Sarah E., Zhou, Wei, Roychowdhury, Tanmoy, Fritsche, Lars G., Gagliano Taliun, Sarah A., Sidore, Carlo, Liu, Yuhao, Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Overton, William, Zhao, Ying, Chen, Jin, Zhang, He, Hornsby, Whitney E., Acheampong, Akua, Grooms, Austen, Schaefer, Amanda, Zajac, Gregory J. M., Villacorta, Luis, Zhang, Jifeng, Brumpton, Ben, Løset, Mari, Rai, Vivek, Lundegaard, Pia R., Olesen, Morten S., Taylor, Kent D., Palmer, Nicholette D., Chen, Yii-Der, Choi, Seung H., Lubitz, Steven A., Ellinor, Patrick T., Barnes, Kathleen C., Daya, Michelle, Rafaels, Nicholas, Weiss, Scott T., Lasky-Su, Jessica, Tracy, Russell P., Vasan, Ramachandran S., Cupples, L. Adrienne, Mathias, Rasika A., Yanek, Lisa R., Becker, Lewis C., Peyser, Patricia A., Bielak, Lawrence F., Smith, Jennifer A., Aslibekyan, Stella, Hidalgo, Bertha A., Arnett, Donna K., Irvin, Marguerite R., Wilson, James G., Musani, Solomon K., Correa, Adolfo, Rich, Stephen S., Guo, Xiuqing, Rotter, Jerome I., Konkle, Barbara A., Johnsen, Jill M., Ashley-Koch, Allison E., Telen, Marilyn J., Sheehan, Vivien A., Blangero, John, Curran, Joanne E., Peralta, Juan M., Montgomery, Courtney, Sheu, Wayne H-H, Chung, Ren-Hua, Schwander, Karen, Nouraie, Seyed M., Gordeuk, Victor R., Zhang, Yingze, Kooperberg, Charles, Reiner, Alexander P., Jackson, Rebecca D., Bleecker, Eugene R., Meyers, Deborah A., Li, Xingnan, Das, Sayantan, Yu, Ketian, LeFaive, Jonathon, Smith, Albert, Blackwell, Tom, Taliun, Daniel, Zollner, Sebastian, Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Pandit, Anita, Zawistowski, Matthew, Kheterpal, Sachin, Brummett, Chad M., Natarajan, Pradeep, Schlessinger, David, Lee, Seunggeun, Kang, Hyun Min, Cucca, Francesco, Holmen, Oddgeir L., Åsvold, Bjørn O., Boehnke, Michael, Kathiresan, Sekar, Abecasis, Goncalo R., Chen, Y. Eugene, Willer, Cristen J., Hveem, Kristian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749177/
https://ncbi.nlm.nih.gov/pubmed/33339817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20086-3
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