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A method for conditional regulation of protein stability in native or near-native form
Here, we report a method to regulate cellular protein levels by introducing a ubiquitin variant between a destabilizing domain (DD) and the regulated protein. When produced in the absence of a stabilizing ligand the DD dominates and the entire fusion protein is processively degraded by the proteasom...
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| 出版年: | Cell Chem Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7749034/ https://ncbi.nlm.nih.gov/pubmed/33007216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.09.004 |
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