Identification of Small Molecule Inhibitors of Neutral Ceramidase (nCDase) Via Target Based High Throughput Screening

There is interest in developing inhibitors of human neutral ceramidase (nCDase) because this enzyme plays a critical role in colon cancer. There are currently no potent nor clinically effective inhibitors for nCDase reported to date, so we adapted a fluorescence-based enzyme activity method to a hig...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Otsuka, Yuka, Airola, Michael V., Choi, Yong-Mi, Coant, Nicolas, Snider, Justin, Cariello, Chris, Saied, Essa M., Arenz, Christoph, Bannister, Thomas, Rahaim, Ron, Hannun, Yusuf A., Shumate, Justin, Scampavia, Louis, Haley, John D., Spicer, Timothy P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749003/
https://ncbi.nlm.nih.gov/pubmed/32734807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555220945283
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