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The human endogenous metabolome as a pharmacology baseline for drug discovery
We have limited understanding of the variation in in vitro affinities of drugs for their targets. An analysis of a highly curated set of 442 interactions between 293 drugs and 79 primary targets reveals that 67% of drug–target affinities have values above that of the corresponding endogenous ligand,...
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| Pubblicato in: | Drug Discov Today |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7748399/ https://ncbi.nlm.nih.gov/pubmed/31226432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2019.06.007 |
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