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Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery()
Metabolism represents the ‘sharp end’ of systems biology, because changes in metabolite concentrations are necessarily amplified relative to changes in the transcriptome, proteome and enzyme activities, which can be modulated by drugs. To understand such behaviour, we therefore need (and increasingl...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science Ltd., Distributed by Virgin Mailing and Distribution
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989035/ https://ncbi.nlm.nih.gov/pubmed/23892182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2013.07.014 |
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