In vivo imaging of the tumor-associated enzyme NCEH1 with a covalent PET probe

Here we report the development of an (18)F-labeled, activity-based small molecule probe targeting the cancer-associated serine hydrolase NCEH1. We undertook a focused medicinal chemistry campaign to simultaneously preserve potent and specific NCEH1 labeling in live cells and animals, while permittin...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Chang, Jae Won, Bhuiyan, Mohammed, Tsai, Hsiu-Ming, Zhang, Hannah J., Li, Gang, Fathi, Shaghayegh, McCutcheon, David C., Leoni, Lara, Freifelder, Richard, Chen, Chin-Tu, Moellering, Raymond E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748380/
https://ncbi.nlm.nih.gov/pubmed/32415874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004762
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