mTOR inhibition impairs extinction memory reconsolidation

Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Learn Mem
Prif Awduron: Radiske, Andressa, Gonzalez, Maria Carolina, Nôga, Diana A., Rossato, Janine I., Bevilaqua, Lia R.M., Cammarota, Martín
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2021
Pynciau:
Brief Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747651/
https://ncbi.nlm.nih.gov/pubmed/33323495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.052068.120
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