Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

The outcome of stroke is greatly influenced by the state of the blood–brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ) proteins, i.e., claudins (Cldns) and the redox regulator occludin. Functions of Cldn3 and occludin at the BBB are largely unknown, particular...

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Bibliografske podrobnosti
izdano v:J Cereb Blood Flow Metab
Main Authors: Winkler, Lars, Blasig, Rosel, Breitkreuz-Korff, Olga, Berndt, Philipp, Dithmer, Sophie, Helms, Hans C, Puchkov, Dmytro, Devraj, Kavi, Kaya, Mehmet, Qin, Zhihai, Liebner, Stefan, Wolburg, Hartwig, Andjelkovic, Anuska V, Rex, Andre, Blasig, Ingolf E, Haseloff, Reiner F
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747158/
https://ncbi.nlm.nih.gov/pubmed/32054373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20904687
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