Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

The outcome of stroke is greatly influenced by the state of the blood–brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ) proteins, i.e., claudins (Cldns) and the redox regulator occludin. Functions of Cldn3 and occludin at the BBB are largely unknown, particular...

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Dades bibliogràfiques
Publicat a:J Cereb Blood Flow Metab
Autors principals: Winkler, Lars, Blasig, Rosel, Breitkreuz-Korff, Olga, Berndt, Philipp, Dithmer, Sophie, Helms, Hans C, Puchkov, Dmytro, Devraj, Kavi, Kaya, Mehmet, Qin, Zhihai, Liebner, Stefan, Wolburg, Hartwig, Andjelkovic, Anuska V, Rex, Andre, Blasig, Ingolf E, Haseloff, Reiner F
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747158/
https://ncbi.nlm.nih.gov/pubmed/32054373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20904687
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