A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant

Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions. In this study, we systematically compared the key properties of seven different plant-made human IgG1 fusion vaccine c...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Diamos, Andrew G., Pardhe, Mary D., Sun, Haiyan, Hunter, Joseph G. L., Kilbourne, Jacquelyn, Chen, Qiang, Mason, Hugh S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746858/
https://ncbi.nlm.nih.gov/pubmed/33343565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576012
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