A Highly Expressing, Soluble, and Stable Plant-Made IgG Fusion Vaccine Strategy Enhances Antigen Immunogenicity in Mice Without Adjuvant

Therapeutics based on fusing a protein of interest to the IgG Fc domain have been enormously successful, though fewer studies have investigated the vaccine potential of IgG fusions. In this study, we systematically compared the key properties of seven different plant-made human IgG1 fusion vaccine c...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Diamos, Andrew G., Pardhe, Mary D., Sun, Haiyan, Hunter, Joseph G. L., Kilbourne, Jacquelyn, Chen, Qiang, Mason, Hugh S.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746858/
https://ncbi.nlm.nih.gov/pubmed/33343565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576012
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