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DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 mediates the recruitment of active P-TEFb to the promoter, which enhances transcriptional elongation. Ho...

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書目詳細資料
發表在:Front Mol Biosci
Main Authors: Song, Yawei, Hu, Gongcheng, Jia, Jinping, Yao, Mingze, Wang, Xiaoshan, Lu, Wenliang, Hutchins, Andrew P., Chen, Jiekai, Ozato, Keiko, Yao, Hongjie
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746802/
https://ncbi.nlm.nih.gov/pubmed/33344510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.618088
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