DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

The bromodomain-containing protein BRD4 has been thought to transmit epigenetic information across cell divisions by binding to both mitotic chromosomes and interphase chromatin. UV-released BRD4 mediates the recruitment of active P-TEFb to the promoter, which enhances transcriptional elongation. Ho...

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Bibliographische Detailangaben
Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Song, Yawei, Hu, Gongcheng, Jia, Jinping, Yao, Mingze, Wang, Xiaoshan, Lu, Wenliang, Hutchins, Andrew P., Chen, Jiekai, Ozato, Keiko, Yao, Hongjie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746802/
https://ncbi.nlm.nih.gov/pubmed/33344510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.618088
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