Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

INTRODUCTION: In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and endothelial injury, aggravating bleeding, as well...

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Bibliographic Details
Published in:Intensive Care Med Exp
Main Authors: Wirtz, Mathijs R., van den Brink, Daan P., Roelofs, Joris J. T. H., Goslings, J. Carel, Juffermans, Nicole P.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746419/
https://ncbi.nlm.nih.gov/pubmed/33336308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-020-00328-w
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