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Amino Acid-Based Synthesis and Glycosidase Inhibition of Cyclopropane-Containing Iminosugars

[Image: see text] Synthesis of four iminosugars fused to a cyclopropane ring is described using l-serine as the chiral pool. The key steps are large-scale preparation of an α,β-unsaturated piperidinone followed by completely stereoselective sulfur ylide cyclopropanation. Stereochemistry of compounds...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Puet, Alejandro, Domínguez, Gema, Cañada, F. Javier, Pérez-Castells, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745444/
https://ncbi.nlm.nih.gov/pubmed/33344836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c04589
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