Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

BACKGROUND: Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known. METHODS: We conducted a double-blind, randomized, placebo-controlled trial evaluating b...

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Veröffentlicht in:N Engl J Med
Hauptverfasser: Kalil, Andre C., Patterson, Thomas F., Mehta, Aneesh K., Tomashek, Kay M., Wolfe, Cameron R., Ghazaryan, Varduhi, Marconi, Vincent C., Ruiz-Palacios, Guillermo M., Hsieh, Lanny, Kline, Susan, Tapson, Victor, Iovine, Nicole M., Jain, Mamta K., Sweeney, Daniel A., El Sahly, Hana M., Branche, Angela R., Regalado Pineda, Justino, Lye, David C., Sandkovsky, Uriel, Luetkemeyer, Anne F., Cohen, Stuart H., Finberg, Robert W., Jackson, Patrick E.H., Taiwo, Babafemi, Paules, Catherine I., Arguinchona, Henry, Goepfert, Paul, Ahuja, Neera, Frank, Maria, Oh, Myoung-don, Kim, Eu S., Tan, Seow Y., Mularski, Richard A., Nielsen, Henrik, Ponce, Philip O., Taylor, Barbara S., Larson, LuAnn, Rouphael, Nadine G., Saklawi, Youssef, Cantos, Valeria D., Ko, Emily R., Engemann, John J., Amin, Alpesh N., Watanabe, Miki, Billings, Joanne, Elie, Marie-Carmelle, Davey, Richard T., Burgess, Timothy H., Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Cardoso, Anabela, de Bono, Stephanie, Bonnett, Tyler, Proschan, Michael, Deye, Gregory A., Dempsey, Walla, Nayak, Seema U., Dodd, Lori E., Beigel, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Massachusetts Medical Society 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745180/
https://ncbi.nlm.nih.gov/pubmed/33306283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2031994
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