Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

BACKGROUND: Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known. METHODS: We conducted a double-blind, randomized, placebo-controlled trial evaluating b...

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Detalhes bibliográficos
Publicado no:N Engl J Med
Main Authors: Kalil, Andre C., Patterson, Thomas F., Mehta, Aneesh K., Tomashek, Kay M., Wolfe, Cameron R., Ghazaryan, Varduhi, Marconi, Vincent C., Ruiz-Palacios, Guillermo M., Hsieh, Lanny, Kline, Susan, Tapson, Victor, Iovine, Nicole M., Jain, Mamta K., Sweeney, Daniel A., El Sahly, Hana M., Branche, Angela R., Regalado Pineda, Justino, Lye, David C., Sandkovsky, Uriel, Luetkemeyer, Anne F., Cohen, Stuart H., Finberg, Robert W., Jackson, Patrick E.H., Taiwo, Babafemi, Paules, Catherine I., Arguinchona, Henry, Goepfert, Paul, Ahuja, Neera, Frank, Maria, Oh, Myoung-don, Kim, Eu S., Tan, Seow Y., Mularski, Richard A., Nielsen, Henrik, Ponce, Philip O., Taylor, Barbara S., Larson, LuAnn, Rouphael, Nadine G., Saklawi, Youssef, Cantos, Valeria D., Ko, Emily R., Engemann, John J., Amin, Alpesh N., Watanabe, Miki, Billings, Joanne, Elie, Marie-Carmelle, Davey, Richard T., Burgess, Timothy H., Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Cardoso, Anabela, de Bono, Stephanie, Bonnett, Tyler, Proschan, Michael, Deye, Gregory A., Dempsey, Walla, Nayak, Seema U., Dodd, Lori E., Beigel, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: Massachusetts Medical Society 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745180/
https://ncbi.nlm.nih.gov/pubmed/33306283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2031994
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