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Transient elevation of temperature promotes cross-linking of α-crystallin-client proteins through formation of advanced glycation endproducts: A potential role in presbyopia and cataracts

The chaperone activity of α-crystallin is important for maintaining the transparency of the human lens. αB-crystallin (αBC) is a long-lived protein in the lens that accumulates chemical modifications during aging. The formation of advanced glycation end products (AGEs) through glycation is one such...

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Bibliografski detalji
Izdano u:Biochem Biophys Res Commun
Glavni autori: Nandi, Sandip K., Rankenberg, Johanna, Glomb, Marcus A., Nagaraj, Ram H.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744422/
https://ncbi.nlm.nih.gov/pubmed/33081971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.10.018
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