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Spatial and temporal heterogeneity of PD-L1 expression and tumor mutational burden (TMB) in gastroesophageal adenocarcinoma (GEA) at baseline diagnosis and after chemotherapy

PURPOSE: Intrapatient heterogeneity of programmed death ligand 1 (PD-L1) expression and tumor mutational burden (TMB) in gastroesophageal adenocarcinoma (GEA) could influence their roles as predictive biomarkers for response to immune checkpoint inhibitors (ICIs). In this retrospective analysis, we...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Zhou, Katherine I., Peterson, Bryan, Serritella, Anthony, Thomas, Joseph, Reizine, Natalie, Moya, Stephanie, Tan, Carol, Wang, Yan, Catenacci, Daniel V. T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744325/
https://ncbi.nlm.nih.gov/pubmed/32820017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2085
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