Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies is that genomic profiling results could commonly differ between the primary and metastatic tumor...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Pectasides, Eirini, Stachler, Matthew D., Derks, Sarah, Liu, Yang, Maron, Steven, Islam, Mirazul, Alpert, Lindsay, Kwak, Heewon, Kindler, Hedy, Polite, Blase, Sharma, Manish R., Allen, Kenisha, O’Day, Emily, Lomnicki, Samantha, Maranto, Melissa, Kanteti, Rajani, Fitzpatrick, Carrie, Weber, Christopher, Setia, Namrata, Xiao, Shu-Yuan, Hart, John, Nagy, Rebecca J., Kim, Kyoung-Mee, Choi, Min-Gew, Min, Byung-Hoon, Nason, Katie S., O’Keefe, Lea, Watanabe, Masayuki, Baba, Hideo, Lanman, Rick, Agoston, Agoston T, Oh, David J., Dunford, Andrew, Thorner, Aaron R., Ducar, Matthew D., Wollison, Bruce M., Coleman, Haley A., Ji, Yuan, Posner, Mitchell C., Roggin, Kevin, Turaga, Kiran, Chang, Paul, Hogarth, Kyle, Siddiqui, Uzma, Gelrud, Andres, Ha, Gavin, Freeman, Samuel S., Rhoades, Justin, Reed, Sarah, Gydush, Greg, Rotem, Denisse, Davison, Jon, Imamura, Yu, Adalsteinsson, Viktor, Lee, Jeeyun, Bass, Adam J., Catenacci, Daniel V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894850/
https://ncbi.nlm.nih.gov/pubmed/28978556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0395
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