Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies is that genomic profiling results could commonly differ between the primary and metastatic tumor...

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Published in:Cancer Discov
Main Authors: Pectasides, Eirini, Stachler, Matthew D., Derks, Sarah, Liu, Yang, Maron, Steven, Islam, Mirazul, Alpert, Lindsay, Kwak, Heewon, Kindler, Hedy, Polite, Blase, Sharma, Manish R., Allen, Kenisha, O’Day, Emily, Lomnicki, Samantha, Maranto, Melissa, Kanteti, Rajani, Fitzpatrick, Carrie, Weber, Christopher, Setia, Namrata, Xiao, Shu-Yuan, Hart, John, Nagy, Rebecca J., Kim, Kyoung-Mee, Choi, Min-Gew, Min, Byung-Hoon, Nason, Katie S., O’Keefe, Lea, Watanabe, Masayuki, Baba, Hideo, Lanman, Rick, Agoston, Agoston T, Oh, David J., Dunford, Andrew, Thorner, Aaron R., Ducar, Matthew D., Wollison, Bruce M., Coleman, Haley A., Ji, Yuan, Posner, Mitchell C., Roggin, Kevin, Turaga, Kiran, Chang, Paul, Hogarth, Kyle, Siddiqui, Uzma, Gelrud, Andres, Ha, Gavin, Freeman, Samuel S., Rhoades, Justin, Reed, Sarah, Gydush, Greg, Rotem, Denisse, Davison, Jon, Imamura, Yu, Adalsteinsson, Viktor, Lee, Jeeyun, Bass, Adam J., Catenacci, Daniel V.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894850/
https://ncbi.nlm.nih.gov/pubmed/28978556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0395
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