A Positive Feed Forward Loop between Wnt/β-Catenin and NOX4 Promotes Silicon Dioxide-Induced Epithelial-Mesenchymal Transition of Lung Epithelial Cells

Silicosis is a chronic fibrotic lung disease caused by the accumulation of silica dust in the distal lung. Canonical Wnt signaling and NADPH oxidase 4 (NOX4) have been demonstrated to play a crucial role in the pathogenesis of pulmonary fibrosis including silicosis. However, the underlying mechanism...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Ma, Jia, Cai, Qian, Yang, Dandan, Yang, Jiali, Xue, Jing, Yu, Miao, Liu, Yingxue, Ma, Fucheng, Li, Feng, Liu, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744200/
https://ncbi.nlm.nih.gov/pubmed/33376577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3404168
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