Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster. Among the metabolites that changed, levels of tyrosine were increased with age in long-lived...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Parkhitko, Andrey A, Ramesh, Divya, Wang, Lin, Leshchiner, Dmitry, Filine, Elizabeth, Binari, Richard, Olsen, Abby L, Asara, John M, Cracan, Valentin, Rabinowitz, Joshua D, Brockmann, Axel, Perrimon, Norbert
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Genetics and Genomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744100/
https://ncbi.nlm.nih.gov/pubmed/33319750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58053
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