S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report that the S-adenosylhomocysteine (SAH) hydrolyzing enzyme...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Greco, Carolina Magdalen, Cervantes, Marlene, Fustin, Jean-Michel, Ito, Kakeru, Ceglia, Nicholas, Samad, Muntaha, Shi, Jiejun, Koronowski, Kevin Brian, Forne, Ignasi, Ranjit, Suman, Gaucher, Jonathan, Kinouchi, Kenichiro, Kojima, Rika, Gratton, Enrico, Li, Wei, Baldi, Pierre, Imhof, Axel, Okamura, Hitoshi, Sassone-Corsi, Paolo
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2020
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744083/
https://ncbi.nlm.nih.gov/pubmed/33328229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5629
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