S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report that the S-adenosylhomocysteine (SAH) hydrolyzing enzyme...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Greco, Carolina Magdalen, Cervantes, Marlene, Fustin, Jean-Michel, Ito, Kakeru, Ceglia, Nicholas, Samad, Muntaha, Shi, Jiejun, Koronowski, Kevin Brian, Forne, Ignasi, Ranjit, Suman, Gaucher, Jonathan, Kinouchi, Kenichiro, Kojima, Rika, Gratton, Enrico, Li, Wei, Baldi, Pierre, Imhof, Axel, Okamura, Hitoshi, Sassone-Corsi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744083/
https://ncbi.nlm.nih.gov/pubmed/33328229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5629
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