S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report that the S-adenosylhomocysteine (SAH) hydrolyzing enzyme...

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Vydáno v:Sci Adv
Hlavní autoři: Greco, Carolina Magdalen, Cervantes, Marlene, Fustin, Jean-Michel, Ito, Kakeru, Ceglia, Nicholas, Samad, Muntaha, Shi, Jiejun, Koronowski, Kevin Brian, Forne, Ignasi, Ranjit, Suman, Gaucher, Jonathan, Kinouchi, Kenichiro, Kojima, Rika, Gratton, Enrico, Li, Wei, Baldi, Pierre, Imhof, Axel, Okamura, Hitoshi, Sassone-Corsi, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744083/
https://ncbi.nlm.nih.gov/pubmed/33328229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5629
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