S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report that the S-adenosylhomocysteine (SAH) hydrolyzing enzyme...

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Pubblicato in:Sci Adv
Autori principali: Greco, Carolina Magdalen, Cervantes, Marlene, Fustin, Jean-Michel, Ito, Kakeru, Ceglia, Nicholas, Samad, Muntaha, Shi, Jiejun, Koronowski, Kevin Brian, Forne, Ignasi, Ranjit, Suman, Gaucher, Jonathan, Kinouchi, Kenichiro, Kojima, Rika, Gratton, Enrico, Li, Wei, Baldi, Pierre, Imhof, Axel, Okamura, Hitoshi, Sassone-Corsi, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744083/
https://ncbi.nlm.nih.gov/pubmed/33328229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5629
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