Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex

Loss of hepatic fructose-1, 6-bisphosphate aldolase B (Aldob) leads to a paradoxical up-regulation of glucose metabolism to favor hepatocellular carcinogenesis (HCC), but the upstream signaling events remain poorly defined. Akt is highly activated in HCC, and targeting Akt is being explored as a pot...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: He, Xuxiao, Li, Min, Yu, Hongming, Liu, Guijun, Wang, Ningning, Yin, Chunzhao, Tu, Qiaochu, Narla, Goutham, Tao, Yongzhen, Cheng, Shuqun, Yin, Huiyong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744066/
https://ncbi.nlm.nih.gov/pubmed/33275593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000803
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