Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Pathogenic mechanisms involved in the autoimmune disorder systemic lupus erythematosus (SLE) remain elusive. However, dysbiosis of the gut microbiota may be involved in disease pathogenesis. We demonstrate that the dysbiotic gut microbiota of lupus-prone mice induced autoimmunity when transferred in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Transl Med
Prif Awduron: Choi, Seung-Chul, Brown, Josephine, Gong, Minghao, Ge, Yong, Zadeh, Mojgan, Li, Wei, Croker, Byron P., Michailidis, George, Garrett, Timothy J., Mohamadzadeh, Mansour, Morel, Laurence
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7739186/
https://ncbi.nlm.nih.gov/pubmed/32641487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax2220
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg