Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats

Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, attenuates EBI by controlling mitochondrial metabolism after SAH....

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Xu, Weilin, Yan, Jun, Ocak, Umut, Lenahan, Cameron, Shao, Anwen, Tang, Jiping, Zhang, Jianmin, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738864/
https://ncbi.nlm.nih.gov/pubmed/33391490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49426
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