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MMP13 Expression Is Increased Following Mutant α-Synuclein Exposure and Promotes Inflammatory Responses in Microglia

α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflam...

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Vydáno v:Front Neurosci
Hlavní autoři: Sánchez, Kathryn, Maguire-Zeiss, Kathleen
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738560/
https://ncbi.nlm.nih.gov/pubmed/33343280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.585544
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