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T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice
IL-2Rα, in part, comprises the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. IL-2Rα deficient mice (IL-2Rα-KO) develop systemic autoimmune disease and die from severe anemia between 18 and 80 days of age. These mice develop kinetically dis...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7738527/ https://ncbi.nlm.nih.gov/pubmed/33319815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78975-y |
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