Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its own to increase lifespan. We first established th...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Bjedov, Ivana, Cochemé, Helena M., Foley, Andrea, Wieser, Daniela, Woodling, Nathaniel S., Castillo-Quan, Jorge Iván, Norvaisas, Povilas, Lujan, Celia, Regan, Jennifer C., Toivonen, Janne M., Murphy, Michael P., Thornton, Janet, Kinghorn, Kerri J., Neufeld, Thomas P., Cabreiro, Filipe, Partridge, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738165/
https://ncbi.nlm.nih.gov/pubmed/33253201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009083
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