Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Plasmodium falciparum Genotype

[Image: see text] The first-line treatments for uncomplicated Plasmodium falciparum malaria are artemisinin-based combination therapies (ACTs), consisting of an artemisinin derivative combined with a longer acting partner drug. However, the spread of P. falciparum with decreased susceptibility to ar...

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Pubblicato in:ACS Pharmacol Transl Sci
Autori principali: Ansbro, Megan R., Itkin, Zina, Chen, Lu, Zahoranszky-Kohalmi, Gergely, Amaratunga, Chanaki, Miotto, Olivo, Peryea, Tyler, Hobbs, Charlotte V., Suon, Seila, Sá, Juliana M., Dondorp, Arjen M., van der Pluijm, Rob W., Wellems, Thomas E., Simeonov, Anton, Eastman, Richard T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737215/
https://ncbi.nlm.nih.gov/pubmed/33344893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00110
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