Identification of a differentiation stall in epithelial mesenchymal transition in histone H3–mutant diffuse midline glioma

BACKGROUND: Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that regulates differentiation and development. H3K27M mutation timing and effect on early embryonic brain...

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Détails bibliographiques
Publié dans:Gigascience
Auteurs principaux: Sanders, Lauren M, Cheney, Allison, Seninge, Lucas, van den Bout, Anouk, Chen, Marissa, Beale, Holly C, Kephart, Ellen Towle, Pfeil, Jacob, Learned, Katrina, Lyle, A Geoffrey, Bjork, Isabel, Haussler, David, Salama, Sofie R, Vaske, Olena M
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736793/
https://ncbi.nlm.nih.gov/pubmed/33319914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giaa136
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