Identification of a differentiation stall in epithelial mesenchymal transition in histone H3–mutant diffuse midline glioma

BACKGROUND: Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that regulates differentiation and development. H3K27M mutation timing and effect on early embryonic brain...

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Vydáno v:Gigascience
Hlavní autoři: Sanders, Lauren M, Cheney, Allison, Seninge, Lucas, van den Bout, Anouk, Chen, Marissa, Beale, Holly C, Kephart, Ellen Towle, Pfeil, Jacob, Learned, Katrina, Lyle, A Geoffrey, Bjork, Isabel, Haussler, David, Salama, Sofie R, Vaske, Olena M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736793/
https://ncbi.nlm.nih.gov/pubmed/33319914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giaa136
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