GENE-11. SHARED LONG NON-CODING RNA DYSREGULATION IN HISTONE H3 K27M GLIOMAS AND PF-A EPENDYMOMAS

Diffuse pediatric gliomas harboring a Histone H3 K27M mutation are significantly more aggressive than H3-wild type gliomas and demonstrate global hypomethylation at the K27 residue(1). As a result, these tumors show global aberrant gene expression, resulting in a primitive, stem-like proliferative c...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Sanders, Lauren, Cheney, Allison, Field, Andrew, Beale, Holly, Kephart, Ellen, Learned, Katrina, Bjork, Isabel, Durbin, Ann, Lyle, Geoff, Pfeil, Jacob, Salama, Sofie, Haussler, David, Vaske, Olena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Genetics/Epigentics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477200/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.082
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