Non-opioid, GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses

BACKGROUND: Burn injury (BI) pain consists of inflammatory and neuropathic components and activates microglia. Nicotinic α7acetylcholine receptors (α7AChRs) expressed in microglia exhibit immuno-modulatory activity during agonist stimulation. Efficacy of selective α7AChR agonist, GTS-21 to mitigate...

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Veröffentlicht in:Anesth Analg
Hauptverfasser: Zhou, Yinhui, Leung-Pitt, Yiuka, Deng, Hao, Ren, Yang, You, Zerong, Kem, William R., Shen, Shiqian, Zhang, Wei, Mao, Jianren, Martyn, J.A. Jeevendra
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736563/
https://ncbi.nlm.nih.gov/pubmed/33264122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005274
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