LACTATE DEHYDROGENASE INHIBITION WITH OXAMATE EXERTS BONE ANABOLIC EFFECT

Cellular bioenergetics is a promising new therapeutic target in aging, cancer, and diabetes as these pathologies are characterized by a shift from oxidative to glycolytic metabolism. We have previously reported such glycolytic shift in aged bone as a major contributor to bone loss in mice. We and ot...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Hollenberg, Alex M., Smith, Charles O., Shum, Laura C., Awad, Hani, Eliseev, Roman A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736558/
https://ncbi.nlm.nih.gov/pubmed/32729639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.4142
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