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Toll-like receptor mediated lysozyme expression in Niemann-Pick disease, type C1

Niemann-Pick type C1 (NPC1) is a rare neurodegenerative disease. In NPC1 mouse cerebella, the antibacterial enzyme, lysozyme (Lyz2), is significantly increased in multiple cell types. Due to its possible role in toxic fibril deposition, we confirmed Lyz2 overexpression in culture in different contro...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Cougnoux, Antony, Yerger, Julia C., Fellmeth, Mason, Serra-Vinardell, Jenny, Wassif, Christopher A., Cawley, Niamh X., Porter, Forbes D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736542/
https://ncbi.nlm.nih.gov/pubmed/33129690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2020.10.009
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