Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish

Charcot-Marie-Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length dependent dysfunction of the peripheral nervous system. Mutations in over 80 diverse genes are associated with CMT, and aminoacyl-tRNA synthetases (ARS) constitute a l...

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Veröffentlicht in:FEBS J
Hauptverfasser: Mullen, Patrick, Abbott, Jamie A., Wellman, Theresa, Aktar, Mahafuza, Fjeld, Christian, Demeler, Borries, Ebert, Alicia M., Francklyn, Christopher S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736457/
https://ncbi.nlm.nih.gov/pubmed/32543048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15449
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