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Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation
Cisplatin is a commonly used chemotherapy agent with significant dose-limiting neurotoxicity resulting in peripheral neuropathy. Although it is postulated that formation of DNA-platinum adducts is responsible for both its cytotoxicity in cancer cells and side effects in neurons, downstream mechanism...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7736304/ https://ncbi.nlm.nih.gov/pubmed/33318563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78896-w |
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