Quinazolinones as Competitive Inhibitors of Carbonic Anhydrase-II (Human and Bovine): Synthesis, in-vitro, in-silico, Selectivity, and Kinetics Studies

Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce the intraocular pressure usually associated w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Front Chem
Hauptverfasser: Khan, Ajmal, Khan, Majid, Halim, Sobia Ahsan, Khan, Zulfiqar Ali, Shafiq, Zahid, Al-Harrasi, Ahmed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736042/
https://ncbi.nlm.nih.gov/pubmed/33335888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.598095
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