A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

PURPOSE: Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP, making the angiopoietin/Tie2 pathway a target for new and potentially disease modifying glaucoma therapies. The goal of the pres...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Li, Guorong, Nottebaum, Astrid F., Brigell, Mitchell, Navarro, Iris D., Ipe, Ute, Mishra, Sarthak, Gomez-Caraballo, Maria, Schmitt, Heather, Soldo, Brandi, Pakola, Steve, Withers, Barbara, Peters, Kevin G., Vestweber, Dietmar, Stamer, W. Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Physiology and Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735951/
https://ncbi.nlm.nih.gov/pubmed/33315051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.14.12
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados